FUNDED PROJECTS:
INFECTIOUS DISEASES
In the 2017 Marató, which dealt with infectious diseases, 214 projects were presented and these were assessed by 103 scientists specialising in these diseases, according to their quality, methodology and relevance. This assessment was managed by the Agency for Health Quality and Assessment of Catalonia, of the Catalan Ministry of Health. In accordance with the proposal of the scientific Advisory Committee of the Fundació La Marató de 3Cat, the Board agreed to distribute €8.302.384 to the following 36 research projects of excellence:
Optimisation of antibiotic prescription in acute uncomplicated infections of the respiratory tract in children: controlled randomised multicentre clinical trial with 2x2 factorial design.
- Dr. Pablo Alonso CoelloInstitut d'Investigacions Biomèdiques Hospital de la Santa Creu i Sant Pau
Fund: 199.648,13 €
Impact of the early detection of resistances to antimicrobials in the reduction of inadequate treatments in bacteraemia caused by enterobacteria.
- Dra. Mónica Ballestero TéllezCatLab - Parc Logístic de Salut
Fund: 87.527,50 €
Respiratory syncytial virus (RSV) in pregnant women and children from sub-Saharan Africa: determination of the incidence of the disease, associated mortality and risk factors.
- Dra. Azucena Bardají AlonsoInstitut de Salut Global de Barcelona - ISGLOBAL
- Dr. Nelson del Rosário TembeCentro de Investigaçao em Saúde de Manhiça Fundaçao Manhiça. Moçambic
Fund: 278.995,05 €
Selective recognition of non-coding RNA and search for new therapeutic targets to combat antibiotic-resistant bacterial infections.
- Dra. Ester Boix BorràsFacultat de Biociències. Universitat Autònoma de Barcelona
Fund: 195.000,00 €
Development of new functional nanoparticles aimed at the lymph node for elimination of latent HIV reservoir.
- Dra. Maria J. Buzón GómezInstitut de Recerca Hospital Universitari Vall d'Hebron - VHIR
Fund: 199.998,75 €
Immunotherapy against the ESKAPE pathogens based on the bacterial proteins of iron capture.
- Dra. Susana Campoy SánchezFacultat de Biociències. Universitat Autònoma de Barcelona
Fund: 180.018,75 €
Identification of biomarkers based on the energy metabolism and oxidative stress in patients with catheter-associated urinary infections and development of biosensors for determination.
- Dr. Jordi Camps AndreuInstitut d'Investigació Sanitària Pere Virgili - IISPV
Fund: 197.500,00 €
Impact of integral molecular tests to reduce antibiotic use in pneumonia acquired in the community: random controlled trial.
- Dr. Jordi Carratalà FernándezInstitut d'Investigació Biomèdica de Bellvitge - IDIBELL
Fund: 199.974,23 €
Impact of loss in clinical follow-up and ageing in the population infected by HIV in Catalonia and the Balearic Islands: population-based cohort study.
- Dr. Jordi Casabona BarbaràAgència de Salut Pública de Catalunya - Institut d'Investigació Germans Trias i Pujol
- Dr. Arkaitz Imaz VacasInstitut d'Investigació Biomèdica de Bellvitge - IDIBELL
Fund: 271.590,00 €
Extracellular vesicles as a new prognostic biomarker for Chagas disease, a chronic infection emerging in Catalonia.
- Dra. M. del Carmen Fernández BecerraInstitut de Salut Global de Barcelona - ISGLOBAL
Fund: 184.375,00 €
Coated liposomal nanocomplexes as drug release systems for the treatment of leishmaniasis.
- Dr. Xavier Fernández BusquetsCentre Esther Koplowitz CEK- Institut de Bioenginyeria de Catalunya
- Dra. Maria ManconiFacoltà di Biologia e Farmacia. Università degli Studi di Cagliari. Itàlia
- Dra. Maria Cristina Riera LizandraFacultat de Farmàcia i Ciències de l'Alimentació. Universitat de Barcelona
Fund: 399.480,85 €
Prevention of infections related to vascular catheters through the functionalisation of catheters impregnated with heat-activatable hydrogels with wide spectrum antimicrobials (FUNCATH).
- Dr. Oriol Gasch BlasiConsorci Hospitalari del Parc Taulí
- Dra. Cristina Garcia de la MariaHospital Clínic i Provincial de Barcelona - Fundació Clínic per a la Recerca Biomèdica
- Dra. Imma Ratera BastardasInstitut de Ciència de Materials de Barcelona ICMBA - CSIC
- Dra. Elena Garcia FruitósInstitut de Recerca i Tecnologia Agroalimentàries - IRTA
Fund: 375.078,75 €
ThermoShots. A new non-existent technology for prevention and treatment of antimicrobial resistance (AMR) and infections associated with biofilms of medical devices.
- Dr. Joan Gavaldà SantapauInstitut de Recerca Hospital Universitari Vall d'Hebron -VHIR
Fund: 199.000,00 €
New prevention strategies against STI/HIV acquisition through elimination of the myeloid-derived suppressor cells.
- Dra. Meritxell Genescà FerrerInstitut de Recerca Hospital Universitari Vall d'Hebron - VHIR
Fund: 199.685,00 €
Challenging the periodontal pathogen Porphyromonas gingivalis through the sortase of its type IX secretion system.
- Dr. F. Xavier Gomis RüthInstitut Biologia Molecular de Barcelona IBMB - CSIC
Fund: 195.500,00 €
Improvement of the microbiological methods associated with the treatment of chronic pulmonary infections by non-tuberculous mycobacteria.
- Dr. Julià González MartínInstitut de Salut Global de Barcelona - ISGLOBAL
Fund: 199.996,88 €
Clinical and microbiological impact of the new antipseudomonals ceftolozane-tazobactam and ceftazidime-avibactam in extremely resistant Pseudomonas aeruginosa infections.
- Dr. Juan Pablo Horcajada GallegoInstitut Mar d'Investigacions Mèdiques - IMIM
Fund: 196.625,00 €
A new approach to combat multiresistance to antibiotics: attacking antigen proteins coded by plasmids of antibiotic resistance.
- Dr. Antonio Juárez GiménezFacultat de Biologia. Universitat de Barcelona
Fund: 196.250,00 €
Subclinical infections in childhood and their impact on health.
- Dr. Emmanouil KogevinasInstitut de Salut Global de Barcelona - ISGLOBAL
Fund: 199.875,00 €
Effectiveness and cost-effectiveness of improving physicians' diagnostic and communicative skills in the adaptation of the antibiotherapy in patients with acute cough in primary care in Catalonia.
- Dr. Carles Llor VilàInstitut d'Investigació en Atenció Primària Jordi Gol - IDIAP
- Dra. Marta Trapero BertranInstitut de Recerca d'Avaluació i polítiques Públiques - IRAPP. Universitat Internacional de Catalunya
- Dr. Antoni Sisó AlmirallFundació d'Atenció Primària de Barcelona
Fund: 377.375,00 €
Evaluation of the public health risk of the atypical and emerging prions.
- Dr. Francesc Josep Llorens TorresInstitut d'Investigació Biomèdica de Bellvitge IDIBELL - CIBER
- Dr. Juan Carlos Espinosa MartínCentro de Investigación en Sanidad Animal CISA - INIA
- Dr. Enric Vidal BarbaInstitut de Recerca i Tecnologia Agroalimentàries - IRTA. Centre Recerca en Sanitat Animal - CRESA
Fund: 400.000,00 €
Extracellular traps of neutrophils and sepsis: clinical implications in kidney transplant.
- Dr. José Miguel López-Botet ArbonaInstitut Mar d'Investigacions Mèdiques - IMIM
Fund: 196.875,00 €
Trampes extracel·lulars de neutròfils i sèpsia: discovery of diagnostic and prognostic markers, and therapeutic targets.
- Dr. Joaquín López-Contreras GonzálezInstitut de Recerca Hospital de la Santa Creu i Sant Pau
Fund: 156.875,00 €
Evaluation of new mutations of cytomegalovirus in the transplant patient suspected of resistance to antivirals through phenotype assay.
- Dra. M. Angeles Marcos MaesoInstitut de Salut Global de Barcelona - ISGLOBAL
Fund: 165.951,25 €
Use of quorum sensing signalling molecules as tools for the diagnosis of bacterial infections.
- Dra. Maria Teresa Martín GómezInstitut de Recerca Hospital Universitari Vall d'Hebron VHIR
- Dra. M. Pilar Marco ColásInstitut de Química Avançada de Catalunya CSIC
Fund: 227.684,84 €
Pilot project for screening of Chagas disease in community pharmacies.
- Dra. Inés Oliveira SoutoInstitut de Recerca Hospital Universitari Vall d'Hebron - VHIR
Fund: 121.150,00 €
Dietary improvement of the anti-infectious components of human milk as a tool for controlling infections in early stages of life (DIM-2-ELI).
- Dr. Francisco José Pérez CanoFacultat de Farmàcia i Ciències de l'Alimentació. Universitat de Barcelona
- Dra. M. Carmen ColladoInstituto de Agroquímica y Tecnología de Alimentos Burjassot - CSIC
Fund: 298.812,50 €
Pseudoenveloped virus particles in exosome candidates for new vaccines for hepatitis A and E.
- Dra. Rosa Maria Pintó SoléFacultat de Biologia. Universitat de Barcelona
- Dra. Margarida Castell EscuerFacultat de Farmàcia i Ciències de l'Alimentació. Fundació Bosch i Gimpera. Universitat de Barcelona
- Dr. Fernando Rodríguez GonzálezInstitut de Recerca i Tecnologia Agroalimentàries - IRTA. Centre Recerca en Sanitat Animal - CRESA
Fund: 399.375,00 €
New polymyxins for the treatment of infections caused by multiresistant bacteria.
- Dr. Francesc Rabanal AngladaFacultat de Química. Universitat de Barcelona
Fund: 200.000,00 €
Study of the reversions of an interferon-γ release test (QuantiFERON-TB Gold Plus) in the study of tuberculosis contacts.*
- Dr. Miguel Santín CerezalesInstitut d'Investigació Biomèdica de Bellvitge - IDIBELL
* The investigator and the centre of this project proposed, and the Board of the Foundation approved, the cofunding of his project with another funding entity. At the Board meeting held on 7 February 2019 it was agreed that €17,758.48 of the total amount of this project will be used to fund part of the project “Discovery of innovative drugs against respiratory viral infections” coordinated by Dr Santiago Vázquez Cruz of the Faculty of Pharmacy and Food Sciences at Barcelona University, for which 100% funding had not been available due to lack of resources. The difference up to the €83,473.75 assigned to Dr Santín's project (€17,560.02) will be allocated to the Foundation's goals of research and awareness-raising.
Fund: 83.473,75 €
Pulmonary and cardiac lesions caused by severe pneumococcal pneumonia: assessment of the effect of corticoids and macrolides in an animal model.
- Dr. Antoni Torres MartíInstitut d'Investigació Biomèdica August Pi i Sunyer - IDIBAPS
Fund: 200.000,00 €
Discovery of innovative drugs against viral respiratory infections.*
- Dr. Santiago Vázquez CruzFacultat de Farmàcia i Ciències de l'Alimentació. Universitat de Barcelona
- Dra. Lieve NaesensRega Institute for Medical Research - University of Leuven. Bèlgica
* At the Board meeting held on 7 February 2019 it was agreed to extend the funding of this project with €17,758.48 originating from of project of Dr Miguel Santín, when the investigator and the centre proposed, and the Board of the Foundation approved, the cofunding of his project with another funding entity. The difference up to the €83,473.75 assigned to Dr Santín's project (€17,560.02) will be allocated to the Foundation's goals of research and awareness-raising.
Fund: 279.791,52 €
From structure to mechanisms by which the Zika virus causes congenital neuropathy.
- Dra. Núria Verdaguer MassanaInstitut Biologia Molecular de Barcelona IBMB - CSIC
Fund: 200.000,00 €
Design and development of a chimerical molecule for the treatment of infections caused by microorganisms multiresistant to antibiotics.
- Dr. Jordi Vila EstapéInstitut de Salut Global de Barcelona - ISGLOBAL
- Dr. Xavier Salvatella GiraltInstitut de Recerca Biomèdica - Parc Científic de Barcelona
Fund: 260.000,00 €
Breaking frown the boundaries of resistance to antimicrobials; seeking new antimicrobials against multiresistant bacteria: a work on polycationic peptides and lipid nanoparticles (BARNAPA).
- Dr. Miquel Viñas CiordiaFacultat de Medicina. Universitat de Barcelona
- Dr. Fernando Albericio PalomeraSchool of Chemistry and Physics. University of KwaZulu-Natal. Sud-àfrica
- Dra. Stefania StefaniLMMAR lab - University of Catania
Fund: 383.276,25 €
Platform for training, auditing and feedback in sepsis for improved implementation of the sepsis code.
- Dr. Juan Carlos Yébenes ReyesHospital de Mataró - Consorci Sanitari del Maresme
Fund: 195.625,00 €